



APYX® MEDICAL CORPORATION
Apyx Medical is an advanced energy technology company with a passion for elevating people's lives through innovative products in our target markets.

THE
RENUVION STORY
Renuvion is the product of years of scientific research, experimentation, refinement, and market testing. Evolving from Apyx Medical’s long history in hospital-based surgery, physicians learned Renuvion was providing controlled heat to tissue which causes a tissue contraction effect.1,2,3,4,5

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REFERENCES:
1. Feldman LS, et al. (eds). The SAGES Manual on the Fundamental Use of Surgical Energy (FUSE), ISBN 978-1-4614-2073-6.
2. Chen SS, Wright NT, Humphrey JD. Heat-induced changes in the mechanics of a collagenous tissue: isothermal free shrinkage. Journal of Biomechanical Engineering 1997:109:372-378.
3. McDonald MB. Conductive Keratoplasty: A Radiofrequency-based Technique for the Correction of Hyperopia. Trans Am Ophthalmol Soc 2005;103:512-536.
4. Chen SS, Humphrey JD. Heat-induced changes in the mechanics of a collagenous tissue: pseudoelastic behavior at 37° C. J Biomech 1998;31:211-216.
5. Wright NT, Humphrey JD. Denaturation of collagen during heating: An irreversible rate process. Annu Rev Biomed Eng; 2002;4:109-128.